ImmunAID is a large scale translational research project whose objective is to optimize the diagnostic, classification and clinical management of patients with auto–inflammatory disorders (AID). Indeed, there is a dramatic unmet need in several rare disorders characterized by huge clinical and biological inflammation, for which no robust and validated classification criteria have been established. The project focuses on rare sporadic AID of unknown pathogenesis and will enable the constitution of homogeneous groups of patients, through European existing cohorts of patients.
This research program is based on an integrated approach and encompasses a full range of expertise spread into a European consortium to bridge the gap between basic research discoveries and clinical applications in auto inflammatory disorders, using a wide spectrum of innovative techniques to characterize potential pathogenic pathways at different steps of the inflammation process (from generation to its resolution), and at different biological scales (from molecular level to cells, tissues or whole organism system). Modelling techniques enabled by recent bioinformatics, biostatistics and mathematical developments (big data and machine learning approach) will be used for the integration of heterogeneous data sets in order to derive and identify novel diagnostic biomarkers and disease classification.
The project results will lead to a better knowledge and understanding of auto-inflammatory mechanisms, as well as the identification of AID signatures able to ascertain the diagnosis of these rare and often misleading conditions. They will enable rapid and accurate diagnosis for patients with suspected AID, and will contribute to facilitate and improve their management and treatment. Indeed, from the novel diagnostic biomarkers and classification, a comprehensive diagnostic tool covering the whole AID spectrum will be developed to be used in daily practice by physicians.
ImmunAID is based on the collaboration of several experts in the field of auto-inflammatory diseases and immunology. The patient perspective will be integrated to the project through various contributions, among them the involvement in communication and dissemination activities, to bring research results to patient community and contribute to improved family counseling, in public relations activities, to strengthen the links between regulators, scientific community and patient organizations across Europe.