TRAPS*
| Epidemiology | |||
|---|---|---|---|
|
Gender ratio |
1 : 1 |
Prevalence |
1/106 |
Disease presentation
Genetic grounds
The disease displays an autosomal dominant inheritance (i.e., receiving the gene from only one parent is enough to develop the disease). The involved mutated gene is TNFRSF1a coding for type 1A receptor to TNF.Main clinical symptoms
Elevated fever with chills
Urticary-like cutaneaous lesions
Abdominal pain
Biological signs
Therapy
- Anti-IL-1 (e.g. Anakinra, Canakinumab)
- Corticosteroids
- Anti-TNFα (Etanercept)
- Anti-IL-6 (e.g. Tocitizumab)
*Tumor necrosis factor Receptor-Associated Periodic Syndrom
