FMF*
| Epidemiology | |||
|---|---|---|---|
|
Gender ration |
1 : 1 |
Prevalence |
1-5/104 |
Disease presentation
Genetic grounds
The disease shows an autosomal recessive inheritance (i.e., each parent must give a mutated gene for a child to develop the disease). The involved mutated gene is MEFV coding for pyrin involved in the pyrin inflammasome.Main clinical symptoms
Elevated fever with chills
Abdominal pain
Joint pain
Biological signs
Therapy
- Colchicin
- Anti-IL-1 (e.g. Anakinra, Canakinumab)
- Anti-IL-6 (e.g. Tocitizumab)
* Familial Mediterranean Fever
